In Chronic Lymphocytic Leukemia, the malignant clone is derived from which cell type?

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Test your knowledge on Blood, Immune, and Hematologic Disorders. Utilize relevant study resources and practice tests to enhance understanding and excel in your upcoming exam! Prepare effectively with multiple-choice questions, hints, and in-depth explanations.

Multiple Choice

In Chronic Lymphocytic Leukemia, the malignant clone is derived from which cell type?

Explanation:
Chronic Lymphocytic Leukemia involves a malignant clone that originates from mature B lymphocytes. These abnormal B cells accumulate in the blood and bone marrow and often carry B-cell surface markers, reflecting their lineage. This differentiates CLL from conditions that arise from other cell types, such as T cells (seen in some T-cell leukemias), plasma cells (as in plasma cell myeloma), or erythrocytes (red blood cells, which are not leukocytes). Therefore, the malignant clone in CLL is derived from B lymphocytes.

Chronic Lymphocytic Leukemia involves a malignant clone that originates from mature B lymphocytes. These abnormal B cells accumulate in the blood and bone marrow and often carry B-cell surface markers, reflecting their lineage. This differentiates CLL from conditions that arise from other cell types, such as T cells (seen in some T-cell leukemias), plasma cells (as in plasma cell myeloma), or erythrocytes (red blood cells, which are not leukocytes). Therefore, the malignant clone in CLL is derived from B lymphocytes.

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