Which diagnostic procedure is used to confirm lymphoma by examining tissue?

Which diagnostic procedure is used to confirm lymphoma by examining tissue?

• A. Lymph node biopsy
• B. CBC
• C. Electrolytes
• D. PET scan

Answer: (A)

Confirming lymphoma requires a tissue diagnosis obtained by biopsy so the pathologist can assess tissue architecture and cellular features, and perform immunophenotyping and genetic studies. A lymph node biopsy—ideally an excisional biopsy of an involved node—provides a complete sample to distinguish lymphoma from reactive lymphadenopathy and to classify the subtype, which guides treatment. Blood tests and imaging help assess extent and effects of disease but do not by themselves confirm lymphoma, since they can be abnormal for other reasons and lack the tissue architecture and immunophenotype needed for a definitive diagnosis.

Confirming lymphoma requires a tissue diagnosis obtained by biopsy so the pathologist can assess tissue architecture and cellular features, and perform immunophenotyping and genetic studies. A lymph node biopsy—ideally an excisional biopsy of an involved node—provides a complete sample to distinguish lymphoma from reactive lymphadenopathy and to classify the subtype, which guides treatment. Blood tests and imaging help assess extent and effects of disease but do not by themselves confirm lymphoma, since they can be abnormal for other reasons and lack the tissue architecture and immunophenotype needed for a definitive diagnosis.