Which therapy is a type of stem cell transplantation used in Multiple Myeloma?

Which therapy is a type of stem cell transplantation used in Multiple Myeloma?

• A. Autologous HSCT
• B. Allogeneic HSCT
• C. Umbilical cord blood transplant
• D. Recombinant immunotherapy

Answer: (A)

In multiple myeloma, using a patient’s own stem cells to rescue the bone marrow after high-dose chemotherapy is the standard transplant approach. This autologous stem cell transplant collects the patient’s hematopoietic stem cells before conditioning chemotherapy (often melphalan), then reinfuses them to restore bone marrow function. Because the cells come from the patient, the risk of graft-versus-host disease is minimal and the procedure supports deeper remissions, improving progression-free and overall survival compared with other transplant types. Donor-based approaches, like allogeneic transplantation, carry higher risks of graft-versus-host disease and treatment-related mortality, so they’re used less commonly in multiple myeloma. Umbilical cord blood transplants are a type of donor transplant with additional limitations for myeloma, and recombinant immunotherapy refers to non-transplant biologic therapies rather than stem cell transplantation.

In multiple myeloma, using a patient’s own stem cells to rescue the bone marrow after high-dose chemotherapy is the standard transplant approach. This autologous stem cell transplant collects the patient’s hematopoietic stem cells before conditioning chemotherapy (often melphalan), then reinfuses them to restore bone marrow function. Because the cells come from the patient, the risk of graft-versus-host disease is minimal and the procedure supports deeper remissions, improving progression-free and overall survival compared with other transplant types.

Donor-based approaches, like allogeneic transplantation, carry higher risks of graft-versus-host disease and treatment-related mortality, so they’re used less commonly in multiple myeloma. Umbilical cord blood transplants are a type of donor transplant with additional limitations for myeloma, and recombinant immunotherapy refers to non-transplant biologic therapies rather than stem cell transplantation.